All Categories, Regenerative & Tissue Research

TB-500

CAS: 77591-33-4

SKU:TB-500

TB-500 is a synthetic peptide fragment derived from thymosin beta-4, investigated in laboratory research for its role in actin dynamics, cytoskeletal organization, and cell-migration–related signaling pathways in controlled experimental models.

Current Lot ID

2602-C105-10-001

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This product is intended for research purposes only.

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Scientific Context & Applications

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View extended technical data, molecular targets, signaling pathways, and historical research timelines for TB-500

Scientific Context

Molecular classification and background.

Overview of molecular classification and research background. TB-500 represents a synthetic fragment of thymosin beta-4 containing the actin-binding motif associated with regulation of actin polymerization. In biochemical and cellular research, this peptide has been characterized for its ability to interact with monomeric G-actin and influence cytoskeletal remodeling processes. In laboratory research models, TB-500 has been examined for its involvement in:

Regulation of actin polymerization and cytoskeletal dynamics
Cellular motility and migration-associated signaling pathways
Endothelial and stromal cell signaling responses
Intracellular processes related to structural organization

All observations are derived from controlled non-clinical experimental systems and interpreted strictly at the molecular and cellular research level.

Laboratory Applications

Experimental models and settings.

Experimental models and investigational settings.

Cell Migration Assays: Utilized in in-vitro systems, including scratch and transwell assays, to study cytoskeletal-dependent cell migration.
Cardiac Cellular Models: Applied in experimental frameworks examining cardiomyocyte signaling and vascular-associated cellular responses.
Ocular Tissue Models: Investigated in laboratory models assessing epithelial cell migration and surface tissue organization.
Inflammatory Signaling Studies: Used in research systems examining cytokine-associated signaling pathways following cellular stress.

All applications are limited to non-clinical research environments.

Scientific References

Peer-reviewed literature data.

Philp D, et al. (Philp D, et al.).“Thymosin beta4 promotes angiogenesis.”FASEB Journal
Huff T, et al. (Huff T, et al.).“Beta-thymosins and actin.”Int. J. Biochem. Cell Biol.
Kleinman HK, et al. (Kleinman HK, et al.).“Thymosin beta4: actin-sequestering protein.”Vitamins and Hormones
Sosne G, et al. (Sosne G, et al.).“Thymosin beta 4 promotes corneal wound healing.”Exp. Eye Res.

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TB-500

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