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PT-141

CAS: 189691-06-3

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SKU:PT-141

PT-141 (Bremelanotide) is a synthetic cyclic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) developed for laboratory investigation of melanocortin receptor signaling pathways.

PT-141
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Current Lot ID
2602-C115-10-001
Third-party analytical validation via HPLC & MS / Sequence matching verified

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This product is intended for research purposes only.

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Technical Specification

Scientific Context & Applications

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View extended technical data, molecular targets, signaling pathways, and historical research timelines for PT-141
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Scientific Context
Molecular classification and background.
PT-141 is classified as a melanocortin receptor agonist with activity across multiple receptor subtypes, including MC1R, MC3R, MC4R, and MC5R, in experimental systems. Melanocortin receptors are G-protein-coupled receptors involved in neuromodulatory and metabolic signaling networks. In laboratory research settings, PT-141 has been examined to explore:
  • Receptor-binding affinity and selectivity
  • Intracellular signaling cascades downstream of melanocortin activation
  • Structural determinants influencing melanocortin receptor engagement
All observations are derived from controlled experimental models and are interpreted strictly at the molecular and cellular level.

Laboratory Applications
Experimental models and settings.
PT-141 is employed in non-clinical research environments as a reference agonist for melanocortin pathway investigation. Documented experimental uses include:
  • Melanocortin Receptor Mapping Applied in receptor-expression systems to characterize MC receptor distribution, signaling strength, and downstream pathway activation.
  • Neuronal Signaling Studies Used in laboratory models to investigate melanocortin-mediated intracellular signaling mechanisms in CNS-derived cell lines.
  • Comparative Peptide Analogue Research Utilized to assess structure–function relationships among α-MSH-derived peptides and related melanocortin agonists.
  • Signal Transduction Assays Applied in vitro to study second-messenger activation and transcriptional responses associated with melanocortin receptor engagement.
All applications remain strictly investigational and confined to laboratory research use only. Research involving PT-141 is exploratory and model-dependent. Results obtained in cellular or animal research systems do not establish safety, efficacy, or applicability beyond controlled laboratory environments. No conclusions regarding clinical, therapeutic, behavioral, or physiological outcomes are implied.

Scientific References
Peer-reviewed literature data.
Selected peer-reviewed literature examining melanocortin receptor signaling and peptide agonist development:
  1. Molinoff PB, et al. Characterization of melanocortin receptor agonists. Annals of the New York Academy of Sciences
  2. Hadley ME, et al. Melanocortin receptor biology and signaling mechanisms. Peptides
  3. Diamond LE, et al. Pharmacological properties of melanocortin peptides in experimental systems. British Journal of Pharmacology
(Studies focused on behavioral or clinical outcomes are intentionally excluded from commerce pages.)
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