All Categories, Immune & Inflammation Research

KPV

CAS: 67727-97-3

SKU:KPV

KPV is a synthetic tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), developed for laboratory investigation of peptide-mediated immune modulation, inflammatory signaling pathways, and cellular transcriptional regulation in controlled research environments.

Current Lot ID

2602-C123-10-001

Third-party analytical validation via HPLC & MS / Sequence matching verified

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This product is intended for research purposes only.

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Technical Specification

Scientific Context & Applications

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View extended technical data, molecular targets, signaling pathways, and historical research timelines for KPV

Scientific Context

Molecular classification and background.

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of alpha-MSH, engineered to retain immunomodulatory and anti-inflammatory signaling properties without the melanogenic effects associated with the full-length peptide. In laboratory research models, KPV has been examined for its involvement in:

Modulation of NF-κB–dependent transcriptional pathways
Regulation of pro-inflammatory cytokine expression
Peptide transport mechanisms mediated by PepT1 transporters
Cellular signaling pathways associated with innate immune responses

All findings are derived from controlled non-clinical experimental systems and interpreted strictly at the molecular and cellular level.

Laboratory Applications

Experimental models and settings.

KPV is utilized in non-clinical research environments as a peptide probe to investigate immune-related signaling and inflammatory modulation. Reported experimental applications include:

Inflammatory Signaling Models: Applied in epithelial and immune cell cultures to study suppression of inflammatory gene transcription.
Intestinal Inflammation Research: Used in experimental systems modeling epithelial immune responses and mucosal signaling pathways.
Antimicrobial Mechanism Studies: Investigated in microbiological assays to examine peptide-mediated host-defense activity.
Tissue Inflammation Models: Applied in laboratory systems evaluating cellular responses associated with inflammation and repair signaling.

Scientific References

Peer-reviewed literature data.

Dalmasso G, et al. (Dalmasso G, et al.).“PepT1-mediated tripeptide KPV.”Gastroenterology
Vavricka SR, et al. (Vavricka SR, et al.).“KPV intestinal inflammation.”Gastroenterology
Cutuli M, et al. (Cutuli M, et al.).“Antimicrobial effects of KPV.”Journal of Leukocyte Biology
Luger TA, et al. (Luger TA, et al.).“Alpha-MSH and inflammation.”Annals NY Acad. Sci.

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KPV

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