All Categories, Endocrine Regulation Research

Ipamorelin

CAS: 170851-70-4

SKU:Ipamorelin

Ipamorelin is a synthetic pentapeptide developed for laboratory investigation of growth hormone secretagogue receptor (GHS-R1a) signaling, intracellular second-messenger pathways, and pulsatile endocrine signaling dynamics in controlled research environments.

Current Lot ID

2602-C118-10-001

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This product is intended for research purposes only.

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Scientific Context

Molecular classification and background.

Ipamorelin is a selective pentapeptide agonist of the Growth Hormone Secretagogue Receptor (GHS-R1a). It was structurally engineered to retain high receptor specificity while minimizing off-target endocrine signaling. In laboratory research models, Ipamorelin has been examined for its involvement in:

G-protein–coupled receptor (GPCR) signaling cascades
Calcium-dependent vesicle exocytosis pathways
Pulsatile hormone-release dynamics at the pituitary level
Receptor-specific signaling decoupled from ACTH and cortisol pathways

All findings are derived from controlled non-clinical experimental systems and interpreted strictly at the molecular and cellular level.

Laboratory Applications

Experimental models and settings.

Ipamorelin is utilized in non-clinical research environments as a selective peptide probe to investigate receptor-mediated endocrine signaling. Reported experimental applications include:

Pituitary Signaling Models – Applied in pituitary cell cultures to study GHS-R1a-mediated intracellular signaling pathways.
Pulse-Generation Research – Used to examine amplitude and frequency characteristics of pulsatile secretion events in endocrine research models.
Catabolic State Models – Applied in laboratory models evaluating nitrogen balance, protein turnover, and metabolic signaling under catabolic conditions.
Enteric and Peripheral Receptor Studies – Investigated for receptor distribution and signaling effects associated with ghrelin-responsive pathways outside the central nervous system.

Scientific References

Peer-reviewed literature data.

Raun K, et al. (Raun K, et al.).“Ipamorelin, the first selective growth hormone secretagogue.”European Journal of Endocrinology
Johansen PB, et al. (Johansen PB, et al.).“Ipamorelin pharmacology.”European Journal of Pharmacology
Svensson J, et al. (Svensson J, et al.).“GH release in response to Ipamorelin.”Journal of Endocrinology
Larsen PJ, et al. (Larsen PJ, et al.).“Distribution of ghrelin receptors.”Journal of Neuroscience

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Ipamorelin

Research Use Only

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