All Categories, Longevity & Cellular Research

5-Amino-1MQ

CAS: 42464-96-0

SKU:5-Amino-1MQ

2602-C127-5-0015-Amino-1MQ is a synthetic, membrane-permeable small molecule examined in laboratory research as a selective inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide metabolism and cellular methylation processes.

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2602-C127-5-001

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This product is intended for research purposes only.

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Scientific Context

Molecular classification and background.

5-Amino-1MQ is classified as a small molecule NNMT inhibitor designed for experimental investigation of nicotinamide methylation pathways. NNMT catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM), influencing downstream availability of NAD⁺ precursors and methyl-donor balance within cells. Inhibition of NNMT in controlled laboratory models has been used to examine intracellular signaling dynamics related to energy metabolism, redox balance, and transcriptional regulation, particularly in adipocyte- and muscle-derived cellular systems. These studies focus on mechanistic pathway interrogation, rather than functional or therapeutic outcomes.

Laboratory Applications

Experimental models and settings.

5-Amino-1MQ is utilized in non-clinical research settings as a biochemical probe for studying NNMT-associated metabolic pathways under controlled experimental conditions. Reported research contexts include:

Adipose Tissue Research Models Examined in adipose-derived cellular and explant systems to evaluate changes in NNMT-related gene expression and intracellular metabolic signaling markers.
Experimental Metabolic Models Investigated in controlled animal or cellular models to explore energy-associated pathway modulation, without extrapolation beyond the experimental system.
Muscle Cell Research Systems Applied in muscle-derived cell cultures to examine NNMT-linked effects on cellular metabolism, differentiation markers, and metabolic flux pathways.
Glucose-Related Signaling Studies Used as a molecular tool in research models assessing metabolic signaling responses, without diagnostic or clinical interpretation.

All applications remain strictly investigational and confined to laboratory research environments.

Scientific References

Peer-reviewed literature data.

Neelakantan H, et al. (Neelakantan H, et al.).“Selective NNMT inhibition.”Biochemical Pharmacology
Dimet-Wiley A, et al. (Dimet-Wiley A, et al.).“NNMT in metabolic disease.”Nature Communications
Kraus D, et al. (Kraus D, et al.).“NNMT and SIRT1.”Nature
Sperber H, et al. (Sperber H, et al.).“NNMT in muscle stem cells.”Nature Medicine

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5-Amino-1MQ

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