All Categories, Neurological & Cognitive Research

Semax

CAS: 80714-61-0

SKU:Semax

Semax is a synthetic heptapeptide analogue of ACTH(4–10) developed for laboratory investigation of neuropeptide signaling, intracellular transcriptional activity, and neurotrophin-associated pathways in controlled research environments.

Current Lot ID

2602-C112-10-001

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This product is intended for research purposes only.

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Technical Specification

Scientific Context & Applications

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View extended technical data, molecular targets, signaling pathways, and historical research timelines for Semax

Scientific Context

Molecular classification and background.

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10). It is devoid of hormonal activity but possesses potent neurotrophic effects. Semax rapidly elevates the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the central nervous system and protects neurons from excitotoxicity.

Laboratory Applications

Experimental models and settings.

Ischemia Models: Used in rat models of focal cerebral ischemia to measure infarct volume reduction.
Neurotrophin Assays: Applied to measure time-dependent increases in BDNF and trkB receptor levels.
ADHD Models: Investigated in spontaneous hypertensive rats (SHR) for effects on attention and impulsivity.
Oxidative Stress: Researched for antioxidant effects in brain homogenates.

Scientific References

Peer-reviewed literature data.

Agadir A, et al. (Agadir A, et al.).“Semax and learning.”Neuroscience Letters
Kaplan A, et al. (Kaplan A, et al.).“Semax neuroprotection.”Neuroscience Research
Dolotov OV, et al. (Dolotov OV, et al.).“Semax and BDNF expression.”Journal of Neurochemistry
Eremin KO, et al. (Eremin KO, et al.).“Semax and nerve growth factor.”Doklady Biological Sciences

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Semax

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